Summary of the NAS 2006
1. In light of the collective evidence … the committee concludes that EPA’s MCLG of 4 mg/L (4ppm) should be lowered
2. Fluoride is an endocrine disruptor in the broad sense of altering normal endocrine function or response
3. Fluorides have the ability to interfere with the functions of the brain and the body by direct and indirect means.
4. Fluoride might be associated with alterations in reproductive hormones, fertility, and Down's syndrome…
5. …a potentially susceptible (to GI irritation, renal tissue and function damage) subpopulation comprises individuals with renal impairments who retain more fluoride than healthy people do
6. … in vitro and animal data suggest the need for more research in this area (of adverse effects on the immune system)